Oklahoma State starting safety Johnny Thomas and receiver Michael Harrison will be ineligible for the season opener.
The team did not announce further details or disclose a timeline for either player's return.
The loss hurts the Cowboys, but it's hardly a huge hit.
Thomas was a first-year starter in 2010, finishing fourth on the team with 63 tackles and three interceptions
He'll need to be back by next week's matchup against Arizona's high-flying pass offense featuring one of the nation's best pass-catch combos in Nick Foles and Juron Criner, but if not, it's not all bad for Oklahoma State.
Thomas' likely replacement, Daytawion Lowe, has long been one of the team's budding stars, prevented from breaking out because of the experience ahead
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